I was trying to wrap my brain around the tune “After You’ve Gone” , which is a tune that eludes me since when I solo over it I can never follow the melody or any resemblence of the melody.
In my attempt to understand this song, here is something that I noticed in the chordal movement of the song that is interesting. Try soloing along to the tune with the following arpeggio movement:

-|–8–|–8–|–7–|–7–|–5–|–5–|–3–|-
-|–8–|–8–|–8–|–9–|–5–|–7–|–3–|-
-|–9–|–8–|–9–|–9–|–6–|–7–|–4–|-
-|–10-|–10-|–9–|–9–|–7–|–7–|–5–|-
-|—–|—–|—–|–7–|—–|–5–|—–|-
-|—–|—–|—–|—–|—–|—–|—–|-
Notice how the chord movement from A to D to G is similar to a movement such as A7 to D7 to G7. If you examine the whole thing, you can see a movement in it similar to C7->F7->A7->E7->A7->D7->G7 . I think I am onto something here but I need to think about it some more.
Here is how I calculated it: C7(sub for C major triad)->F7(sub for Cm6)->A7(A7 is a secondary dominant chord in the key of Em[G] )->E7(sub for E maj chord)->A7(a sub for Amaj chord)->D7(sub for Dmaj chord)->G7(sub for G major chord).
I am really stretching here with my crazy way to think about how to play over this tune but maybe someone who reads this can email me a better idea or use the idea I have.
Here is an example of me trying to play over this tune.